Butch Jones said at his Tuesday press conference that the ankle injury sustained by RB Darrin Williams is serious.
Williams will be held out Friday against Louisville and the following week against USF. After that, Williams will be re-evaluated by the staff. Jones said, at that point, there is a chance he could be ruled out for the year.
"We are continuing to address it," Jones said. "There is a chance we could have him back in a couple weeks and a chance he could be out the rest of the year."
Jones deferred any technical analysis of the injury to the training staff, but said it is an issue with the bone and is more than just a high ankle sprain.
Williams had 20 carries for 144 yards in three games. Most of those came against Indiana State when he rushed 13 times for 117 yards.
"It's very unfortunate because we thought he was playing extremely well for us," Jones said. "Again, it gets back now our depth becomes a concern at the running back spot next week."
Isaiah Pead will continue to start with John Goebel as his backup. The third running back will likely be George Winn, who has played in mop up time against Indiana State and Miami.
He has 30 carries for 129 yards on the season.