DePaul guard Sam Quigley foreshadowed her lights-out shooting in Tuesday's contest when drilled a 3-pointer 23 seconds into the game.
The No. 12/ 17 Blue Demons handed the Cincinnati women's basketball team their fifth-straight defeat 67-48 at Fifth Third Arena.
Quigley matched a season-best 23 points while knocking down seven triples on 12 attempts.
The biggest one came at the first period buzzer, a backbreaking halfcourt heave. It was her fifth triple of the half and capped a 13-2 run from the Blue Demons to stretch their lead to 18.
"That last [second] shot was crazy," UC guard Shareese Ulis said.
Cincinnati (8-11, 1-6) took away DePaul's interior presence with double teams but succumbed to the senior's hot shooting from behind the arc.
"We as coaches going into the game decided that we wanted to take away the inside game," head coach Jamelle Elliott said. "[To] try to disrupt the low post as much as possible and try to get out on the shooters as quickly as we can. But obviously [Quigley] is first team all-Big East for a reason. We picked our poison, unfortunately Quigley was able to knock down threes on a consistent basis."
A 10-3 run from UC at the 3:36 mark had trimmed a 14-point deficient to seven before Quigley sparked DePaul's three-minute blitz by nailing another 3-ball.
UC could not cut the lead below 15 in the final 20 minutes.
The Bearcats shot nearly 47 percent in the closing half.
"I'm always happy when [we're] able to shoot the ball and make it, because we have been shooting so inconsistent recently," Elliott said.
Ulis cashed in 18 points to pace the Bearcats in 35 minutes of action. The guard found her comfort zone going off for nine-straight points over a two-minute period with under 10 minutes remaining.
"I need to do everything I can do to give my team a chance to win," Ulis said. "We ended the [first] half not scoring so I wanted to make sure we didn't do the same thing in the second half."
The Cats were outsized but gained a 40-39 edge on the glass. They held DePaul's forwards in check with just one player hitting double figures in points. Elliott said she was pleased with the team's fight in the paint despite their lack of height.
DePaul capitalized on the Bearcats 19 turnovers with 12 fast break points.
"They looked to get into the passing lanes and they were switching screens," Elliott said. "They were able to switch and get into the passing lanes, which led to them getting some transition baskets."
Cincinnati faced an early up-hill climb trailing by 13 due to cold shooting until guard Bjonee Reaves ended a seven-minute drought without a field goal at the 11:23 mark.
Elliott and the Bearcats will face her former team No. 2 UConn Saturday at 2 p.m. in Fifth Third Arena.