For the second-straight contest Cincinnati was dealt a defeat from a winless Big East team.
The Bearcats (8-16, 1-11 Big East) lost their 10th-consectuive game 64-44 to Villanova on Tuesday at the Pavilion.
Wildcat guard Lindsay Kimmel nailed three-consecutive 3-pointers in a crucial three-minute stretch at the beginning of the second half to extend the 12-point lead at the break to 19.
Following the barrage from Kimmel, UC couldn't trim the lead below 18.
Kimmel notched a career-best 23 points and went 7-14 from distance. Freshman Devon Kane also netted a career-high 13.
Cincinnati freshman Jeanise Randolph scored a career-best 20 points on near perfect shooting 10-11 while leading all rebounders with seven. Randolph became the first rookie to drop 20 since Jan. 17, 2009.
Guard Shareese Ulis contributed 11 points with 3-5 shooting from beyond the arc.
The five-minute mark of the first half was the last time Cincinnati would be behind by single digits, 24-15.
The Wildcats (9-16, 1-11) turned 14 UC miscues into 14 points. Villanova forward Laura Sweeney was the catalyst with a game-high five steals.
UC had a short bench once again with seven-healthy bodies. Villanova outscored UC's reserves by a 21-0 margin.
With the exception of Kimmel's hot shooting the rest of team went 3-18 from behind the arc. Taking away clean looks for Villanova was a main focus for UC head coach Jamelle Elliot prior to the game.
"Disrupt Villanova's offense as much as possible," Elliott said. "Crowd them and make them put the ball on the floor, something that they don't want to do a whole lot of."
Villanova No. 7 in the Big East in 3-point field goal percentage defense limited UC to 33 percent shooting.
Cincinnati tips off with Providence College Saturday at 2 p.m. at Fifth Third Arena.